翻訳と辞書 Words near each other ・ Cycling at the 1968 Summer Olympics – Men's individual road race ・ Cycling at the 1968 Summer Olympics – Men's sprint ・ Cycling at the 1968 Summer Olympics – Men's tandem ・ Cycling at the 1968 Summer Olympics – Men's team pursuit ・ Cycling at the 1968 Summer Olympics – Men's team time trial ・ Cycling at the 1970 Asian Games ・ Cyclin E ・ Cyclin E1 ・ Cyclin E2 ・ Cyclin H ・ Cyclin K ・ Cyclin O ・ Cyclin T1 ・ Cyclin T2 ・ Cyclin-dependent kinase ・ Cyclin-dependent kinase 1 ・ Cyclin-dependent kinase 10 ・ Cyclin-dependent kinase 2 ・ Cyclin-dependent kinase 3 ・ Cyclin-dependent kinase 4 ・ Cyclin-dependent kinase 5 ・ Cyclin-dependent kinase 6 ・ Cyclin-dependent kinase 7 ・ Cyclin-dependent kinase 8 ・ Cyclin-dependent kinase 9 ・ Cyclin-dependent kinase complex ・ Cyclin-dependent kinase inhibitor 1C ・ Cyclin-dependent kinase inhibitor protein ・ Cyclin-dependent kinase regulatory subunit family ・ Cycling Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Cyclin-dependent kinase 1 ： ウィキペディア英語版 Cyclin-dependent kinase 1 Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine kinase, and is a key player in cell cycle regulation. It has been highly studied in the budding yeast ''S. cerevisiae'', and the fission yeast ''S. pombe'', where it is encoded by genes ''cdc28'' and ''cdc2'', respectively. In humans, Cdk1 is encoded by the ''CDC2'' gene. With its cyclin partners, Cdk1 forms complexes that phosphorylate a variety of target substrates (over 75 have been identified in budding yeast); phosphorylation of these proteins leads to cell cycle progression. == Structure == Cdk1 is a small protein (approximately 34 kilodaltons), and is highly conserved. The human homolog of Cdk1, ''CDC2'', shares approximately 63% amino-acid identity with its yeast homolog. Furthermore, human ''CDC2'' is capable of rescuing fission yeast carrying a ''cdc2'' mutation.〔 Cdk1 is comprised mostly by the bare protein kinase motif, which other protein kinases share. Cdk1, like other kinases, contains a cleft in which ATP fits. Substrates of Cdk1 bind near the mouth of the cleft, and Cdk1 residues catalyze the covalent bonding of the γ-phosphate to the oxygen of the hydroxyl serine/threonine of the substrate. In addition to this catalytic core, Cdk1, like other cyclin-dependent kinases, contains a T-loop, which, in the absence of an interacting cyclin, prevents substrate binding to the Cdk1 active site. Cdk1 also contains a PSTAIRE helix, which, upon cyclin binding, moves and rearranges the active site, facilitating Cdk1 kinase activities. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Cyclin-dependent kinase 1」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.